Isolation and characterization of a light chain variable region gene for human rheumatoid factors

نویسندگان

  • P P Chen
  • D L Robbins
  • F R Jirik
  • T J Kipps
  • D A Carson
چکیده

Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 166  شماره 

صفحات  -

تاریخ انتشار 1987